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임순성
  • 분야

    천연물연구

  • 성명

    국문 임순성

  • 직위

    교수

  • 연구실

    천연물화학(8510호)

  • 연락처

    033-248-2133

  • 이메일

학력

1986 ~ 1990 고려대학교 화학전공(학사)

1990 ~ 1994 고려대학교 유기화학전공(석사)

1995 ~ 2000 고려대학교 유기화학전공(박사)

 

주요경력

2008.03 ~ 한림대학교 자연과학대 식품영양학과(교수)
2003.04 ~ 2008.02 한림대학교 RRC-RIC(연구교수)
2001.12 ~ 2003.01 스위스 로잔대 IPP(박사후 연수)
2001.02 ~ 2001.11 서울대학교(박사후 연수)
2000.12 ~ 2001.01 일본 동북대(객원연구원)
1994.09 ~ 2000.08 서울대학교 천연물과학연구소 조교(연구원)
1992.09 ~ 2003.08 고려대학교 화학과(조교 및 시간강사) 

연구 및 저서

■ 천연물연구
- UPLC, MPLC, HSCCC 및 open column chromatography를 이용한 천연물로부터 유효물질의 분리/정제/구조결정
- 신규 On-line bioassay 및 enzyme binding assay (UF)를 활용하여 신속한 생리활성 물질의 검색
- 반응표면분석법 (RSM)을 이용한 최적화 추출공정 개발 및 Scale up 공정 연구
- CYP450 효소를 이용한 천연물과 의약품간의 약물상호작용 (Drug-Drug Interaction, DDI) 연구
- 천연물의 생물전환(biotransformation) 대사체 연구 (PCA & Metabolites)
- 유효물질을 기반으로 한 흡수증대를 갖는 제형 개발 (Solubility, PAMPA 개선)
- 효소합성법 (Enzymatic synthesis method)를 이용한 폴리페놀 유도체의 친환경 합성법 개발

 

■ 주요 연구 천연물
- 감초/단삼/짚신나물/미역취/차즈기/멀꿀나무/다릅나무/털장구채/산옥잠화/쥐오줌풀/곤충 효소 가수분해물 (yellow worm)/천마/MACA의 생리활성 성분의 구조규명 연구 및 원료표준화 (CMC) 연구

 

■ 기능성(생리활성) 연구 분야
- 당뇨 및 당뇨합병증 치료소재 개발 (합성화합물 포함한 천연물소재)
- 개별인정형 건강기능식품 소재 개발 (식후혈당, 체지방감소, 뼈/관절 건강, 혈중중성지방개선)
- 천연물로부터 기능성화장품 소재 개발 (미백/주름/자외선차단/탈모방지)
- 천연물 유효물질의 합성유도체로부터 통증 치료 소재
-  암세포 특이적 세포사 물질(합성신약) 연구

기타

■ 논문 
1. Ischemia-Induced Cognitive Impairment Is Improved via Remyelination and Restoration of Synaptic Density in the Hippocampus after Treatment with COG-Up® in a Gerbil Model of Ischemic Stroke. Veterinary Sciences 8 (12), 321 (2021)
2. Asaronic acid inhibits ER stress sensors and boosts functionality of ubiquitin-proteasomal degradation in 7β-hydroxycholesterol-loaded macrophages. Phytomedicine 92, 153763 (2021)
3. Purple corn extract alleviates 2, 4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice. Animal cells and systems 25 (5), 272-282 (2021)
4. Extracts from the Leaves of Cissus verticillata Ameliorate High-Fat Diet-Induced Memory Deficits in Mice. Plants 10 (9), 1814 (2021)
5. Separation and Identification of Antioxidants and Aldose Reductase Inhibitors in Lepechinia meyenii (Walp.) Epling (2021) 
6. Metformin‑induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells. Scientific Reports 11 (1), 1-13 (2021)
7. The  Anti-Inflammatory and  the Antinociceptive Effects of Mixed Agrimonia pilosa Ledeb.  and Salvia miltiorrhiza Bunge  Extract. Plants 10 (6), 1234 (2021)
8. Cissus verticillata Extract Decreases Neuronal Damage Induced by Oxidative Stress in HT22 Cells and Ischemia in Gerbils by Reducing the Inflammation and Phosphorylation of MAPKs. Plants 10 (6), 1217 (2021)
9. Defatted Seeds of Oenothera biennis as a Potential Functional Food Ingredient for Diabetes. Foods 10 (3), 538 (2021)
10.  Purple corn extract (PCE) alleviates cigarette smoke (CS)-induced DNA damage in rodent blood cells by activation of AMPK/Foxo3a/MnSOD pathway. Animal Cells and Systems 25 (1), 65-73 (2021)
11.  Valeriana rigida Ruiz & Pav. Root Extract: A New Source of Caffeoylquinic Acids with Antioxidant and Aldose Reductase Inhibitory Activitie. Foods 10 (5), 1079 (2021)
12.  Effect of Extract and Synthesized Derivatives of Isolated Compound from Symplocos chinensis f. Pilosa Ohwi on Neuropathic Pain in Mice. Molecules 26 (6), 1639 (2021)
13.  Increased Calbindin D28k Expression  via Long-Term Alternate-Day  Fasting  Does  Not  Protect against Ischemia-Reperfusion Injury:  A  Focus on Delayed Neuronal Death,  Gliosis and Immunoglobulin G Leakage. International Journal of Molecular Sciences 22 (2), 644 (2021)
14.  Chemical Composition of a Novel Distillate from Fermented Mixture of Nine Anti-Inflammatory Herbs and Its UVB-Protective Efficacy in Mouse Dorsal Skin via Attenuating Collagen Disruption and Inflammation. Molecules 26 (1), 124 (2021)
15.  Efficient Separation of Phytochemicals from Muehlenbeckia volcanica (Benth.) Endl. by Polarity-Stepwise Elution Counter-Current Chromatography and Their Antioxidant, Antiglycation, and Aldose Reductase Inhibition Potentials. Molecules 26 (1), 224 (2021)
16.  Licochalcone A inhibits hypoxia-inducible factor-1α accumulation by suppressing mitochondrial respiration in hypoxic cancer cells. Biomedicine & Pharmacotherapy 133, 111082 (2021)
17.  Linarin and its aglycone acacetin abrogate actin ring formation and focal contact to bone matrix of bone-resorbing osteoclasts through inhibition of alpha v beta 3 integrin and core-linked CD44. PHYTOMEDICINE (2020)
18.  Constituents from Solidago virgaurea var. gigantea and their inhibitory effect on lipid accumulation. FITOTERAPIA (2020)
19.  Retention mechanism of pH-peak-focusing in countercurrent chromatographic separation of baicalin and wogonoside from Scutellaria baicalensis Georgi. JOURNAL OF SEPARATION SCIENCE (2020)
20.  An Off-Line DPPH-GC-MS Coupling Countercurrent Chromatography Method for Screening, Identification, and Separation of Antioxidant Compounds in Essential Oil. ANTIOXIDANTS (2020)
21.  Asaronic Acid Inhibited Glucose-Triggered M2-Phenotype Shift Through Disrupting the Formation of Coordinated Signaling of IL-4R alpha-Tyk2-STAT6 and GLUT1-Akt-mTOR-AMPK. NUTRIENTS (2020)
22.  Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice. FOOD SCIENCE  NUTRITION (2020)
23.  Anti-obesity effect of Melandrium firmum Rohrbach extract in 3T3-L1 cells and high-fat diet-induced obese C57BL/6N mice. FOOD SCIENCE  NUTRITION (2020)
24.  Antinociceptive effect of chrysin in diabetic neuropathy and formalin-induced pain models. ANIMAL CELLS AND SYSTEMS (2020)
25.  Discovery of Epinastine-NSAID Hybrids as Potential Anti-inflammatory Agents: Synthesis and In Vitro Nitric Oxide Production Inhibitory Activity Study (2020)
26.  Melandrium firmum Extract Promotes Hair Growth by Modulating 5 alpha-Reductase Activity and Gene Expression in C57BL/6J Mice. ANNALS OF DERMATOLOGY (2019)
27.  Affinity measurement of ligands in Perilla frutescens extract towards alpha-glucosidase using affinity-based ultrafiltration-high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2019)
28.  Antinociceptive effect of single components isolated from Agrimonia pilosa ledeb. Extract. Scientia Pharmaceutica (2019)
29.  Asaronic Acid Attenuates Macrophage Activation toward M1 Phenotype through Inhibition of NF-kappa B Pathway and JAK-STAT Signaling in Glucose-Loaded Murine Macrophages. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)
30.  Liposomal formulation and pharmacokinetic study of CPD409, a novel sodium channel blocker. Journal of Pharmaceutical Investigation. Journal of Pharmaceutical Investigation (2019)
31.  Effects of resveratrol and oxyresveratrol on hippocampal cell death induced by kainic acid. ANIMAL CELLS AND SYSTEMS (2019)
32.  Target guided isolation of potential tyrosinase inhibitors from Otholobium pubescens (Poir.) JW Grimes by ultrafiltration, high-speed countercurrent chromatography and preparative HPLC. INDUSTRIAL CROPS AND PRODUCTS (2019)
33.  Fermented dried Citrus unshiu peel extracts exert anti-inflammatory activities in LPS-induced RAW264.7 macrophages and improve skin moisturizing efficacy in immortalized human HaCaT keratinocytes. PHARMACEUTICAL BIOLOGY (2019)
34.  Aldose Reductase, Protein Glycation Inhibitory and Antioxidant of Peruvian Medicinal Plants: The Case of Tanacetum parthenium L. and Its Constituents. MOLECULES (2019)
35.  Chemical Compositions of the Volatile Oils and Antibacterial Screening of Solvent Extract from Downy Lavender. FOODS (2019)
36.  Novel aldose reductase inhibitory and antioxidant chlorogenic acid derivatives obtained by heat treatment of chlorogenic acid and amino acids. Food Chemistry (2018)
37.  Lipid-Lowering Effects of Medium-Chain Triglyceride-Enriched Coconut Oil in Combination with Licorice Extracts in Experimental Hyperlipidemic Mice. Journal of Agricultural and Food Chemistry (2018)
38.  Pistafolin B is the major aldose reductase inhibitor of the pods of tara [Caesalpinia spinose (Molina) Kuntze] Industrial Crops and Products (2018)
39.  Anti-Nociceptive Effect and Standardization from Mixture of Agrimonia pilosa Ledeb and Salvia miltiorrhiza Bunge Extracts. Journal of Medicinal Food (2018)
40.  Antioxidant activity and inhibitory effects of 2-hydroxy-3-methylcyclopent-2-enone isolated from ribose-histidine Maillard reaction products on aldose reductase and tyrosinase. Food and Function (2018)
41.  An: In vitro affinity-based method for studying herb-drug interactions for direct identification of cytochrome P450 1A2, 3A4, and 2C9 specific ligands from herbal extracts using ultrafiltration-high performance liquid chromatography. RSC Advances (2018)
42.  Anti-glycation, carbonyl trapping and anti-inflammatory activities of chrysin derivatives. Molecules (2018) 
43.  Antiobesity Effect of Astilbe chinensis Franch. et Savet. Extract through Regulation of Adipogenesis and AMP-Activated Protein Kinase Pathways in 3T3-L1 Adipocyte and High-Fat Diet-Induced C57BL/6N Obese Mice. Evidence-based Complementary and Alternative Medicine (2018)
44.  Evaluation of aldose reductase, protein glycation, and antioxidant inhibitory activities of bioactive flavonoids in Matricaria recutita L. and their structure-activity relationship. Journal of Diabetes Research (2018)
45.  Screening In Vitro Targets Related to Diabetes in Herbal Extracts from Peru: Identification of Active Compounds in Hypericum laricifolium Juss. by Offline High-Performance Liquid Chromatography. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
46.  Characterization of DHDP, a novel aldose reductase inhibitor isolated from Lysimachia christinae. JOURNAL OF FUNCTIONAL FOODS (2017)
47.  Anti-Obesity Effect of the Above-Ground Part of Valeriana dageletiana Nakai ex F. Maek Extract in High-Fat Diet-Induced Obese C57BL/6N Mice. NUTRIENTS (2017)
48.  Protein Tyrosine Phosphatase 1β (PTP1β) Inhibitory Compounds Isolated from Prunella vulgaris. Chemistry of Natural Compounds (2017)
49.  Alantolactone and Isoalantolactone Prevent Amyloid β(25-35)-induced Toxicity in Mouse Cortical Neurons and Scopolamine-induced Cognitive Impairment in Mice. PHYTOTHERAPY RESEARCH (2017)
50.  Bioactivity-guided isolation and identification of anti-adipogenic compounds from Sanguisorba officinalis L. FASEB JOURNAL (2017)
51.  Screening of Peruvian Medicinal Plants for Tyrosinase Inhibitory Properties: Identification of Tyrosinase Inhibitors in Hypericum laricifolium Juss. MOLECULES (2017)
52.  Phytochemical Analysis of Agrimonia pilosa Ledeb, Its Antioxidant Activity and Aldose Reductase Inhibitory Potential. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
53.  Rapid High Performance Liquid Chromatography Determination and Optimization of Extraction Parameters of the -Asarone Isolated from Perilla frutescens L. MOLECULES (2017)
54.  Analytical Method for the Validation of Three Polyphenols as a Marker Compound for the Standardization of Solidago virgaurea subsp gigantea Extracts and Antiadipogenesis of Harvesting Time and Location. JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY (2017)
55.  Anti-obesity effect of Solidago virgaurea var. gigantea extract through regulation of adipogenesis and lipogenesis pathways in high-fat diet-induced obese mice (C57BL/6N) FOOD  NUTRITION RESEARCH (2017)
56.  Antidiabetic Effect of Fresh Nopal (Opuntia ficus-indica) in Low-Dose Streptozotocin-Induced Diabetic Rats Fed a High-Fat Diet. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)
57.  Chemo-enzymatic synthesis of vinyl and L-ascorbyl phenolates and their inhibitory effects on advanced glycation end products. FOOD CHEMISTRY (2017)
58.  Competitive binding experiments can reduce the false positive results of affinity-based ultrafiltration-HPLC: A case study for identification of potent xanthine oxidase inhibitors from Perilla frutescens extract. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2017)
59.  Comprehensive evaluation of the antioxidant capacity of Perilla frutescens leaves extract and isolation of free radical scavengers using step-wise HSCCC guided by DPPH-HPLC. INTERNATIONAL JOURNAL OF FOOD PROPERTIES (2017)
60.  Comprehensive profiling of minor tyrosinase inhibitors from Gastrodia elata using an off-line hyphenation of ultrafiltration, high-speed countercurrent chromatography, and high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY A (2017)
61.  Enzymatic Synthesis of a Novel Kaempferol-3-O-beta-D-glucopyranosyl(1 -> 4)-O-alpha-D-glucopyranoside Using Cyclodextrin Glucanotransferase and Its Inhibitory Effects on Aldose Reductase, Inflammation, and Oxidative Stress. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)
62.  Inhibitory Activities of Stauntonia hexaphylla Leaf Constituents on Rat Lens Aldose Reductase and Formation of Advanced Glycation End Products and Antioxidant. BIOMED RESEARCH INTERNATIONAL (2017)
63.  Investigation of the antioxidant and aldose reductase inhibitory activities of extracts from Peruvian tea plant infusions. FOOD CHEMISTRY (2017)
64.  Rapid Identification and Isolation of Inhibitors of Rat Lens Aldose Reductase and Antioxidant in Maackia amurensis. BIOMED RESEARCH INTERNATIONAL (2017)
65.  Synergetic hepatoprotective effects of korean red ginseng and pueraria radix on the liver damaged-induced by carbon tetrachloride (CCL4) in mice. Natural Product Sciences (2017)
66.  alpha-Asarone blocks 7 beta-hydroxycholesterol-exposed macrophage injury through blocking elF2 alpha phosphorylation and prompting beclin-1-dependent autophagy. ONCOTARGET (2017) 


■ 주요 특허 등록 
1. 코르너스 오블롱가 추출물을 이용한 항염증용 조성물, 제10-2226439-0000, 2021
2. 코르너스 오블롱가 추출물을 이용한 궤양성 대장염 개선용 조성물, 제10-2226448-0000, 2021
3. 유통기한이 향상되고 오메가-3가 증가된 생들기름 제조방법, 제10-2249821-0000, 2021
4. 노루궁뎅이버섯 가수분해물을 유효성분으로 포함하는 항산화 및 항비만 조성물, 제10-2144513-0000, 2020
5. 로로통 추출물을 유효성분으로 함유하는 통증 예방 또는 치료용 조성물, 제10-2109498-0000, 2020
6. 소목(Caesalpinia eriostachys Benth) 추출물을 유효성분으로 함유하는 통증 예방 또는 치료용 조성물, 제10-2088768-0000, 2020
7. Combretum farinosum Kunth 추출물을 유효성분으로 함유하는 통증 예방 또는 치료용 조성물, 제10-2073796-0000, 2020
8. 신규한 크리신 유도체 화합물을 유효성분으로 포함하는 당뇨합병증의 예방 또는 치료용 약학 조성물, 제10-2032739-0000, 2019
9. 짚신나물 및 단삼의 추출물을 유효성분으로 포함하는 조성물 및 이의 제조방법, 제10-2009669-0000, 2019
10. 사이클로덱스트린 글루카노트랜스퍼레이즈를 이용한 수용성이 증대된 아스트라갈린의 당전이 화합물의 제조방법 및 이로부터 제조된 아스트라갈린의 당전이 화합물을 함유하는 조성물, 제10-1986789-0000, 2019
11. 코코넛 오일의 상온 유동성 개선방법, 제10-1978158-0000, 2019
12. 미역취 추출물을 함유하는 항비만 식품 조성물 및 이의 제조방법, 제10-1952257-0000, 2019
13. 짚신나물 및 단삼의 추출물을 유효성분으로 포함하는 조성물 및 이의 제조방법, 제10-1952242-0000, 2019
14. 멀꿀 나무 추출물을 함유하는 당뇨합병증의 예방 또는 치료용 약학 조성물, 제10-1883870-0000, 2018
15. 페루산 포라덴드론 콰드랭귤러 식물 추출물을 함유하는 당뇨합병증의 예방 또는 치료용, 제10-1880164-0000, 2018
16. 야관문 추출물을 유효성분으로 포함하는 피부미백용 조성물, 제10-1876319-0000, 2018
17. 5원 헤테로사이클릭 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물, 제10-1844984-0000, 2018
18. 미역취 추출물을 함유하는 항비만 식품 조성물 및 이의 제조방법, 제10-1754149-0000, 2017
19. 차즈기 추출물을 포함하는 콜레스테롤 대사 관련 혈관질환 개선용 식품 조성물 및 이의 제조방법, 제10-1733048-0000, 2017

강영희
  • 분야

    영양생리학

  • 성명

    국문 강영희

  • 직위

    석좌교수

  • 연구실

    생명과학관 8617호

  • 연락처

    033-248-2132

  • 이메일

학력

- 1981 서울대학교 학사

- 1983 Drexel University 석사

- 1988 Rutgers University 박사

주요경력

- 2018. 9. 1 ~ 현재 : 식품영양학과장

- 2015 ~ 현재 한국과학기술한림원 농수산학부 정회원

- 2013 ~ 2015 한림대학교 교무처장

- 2013 ~ 2015 식품영양학과 BK21 plus 사업팀장

- 2013 ~ 2013 한림대학교 자연과학대학 학장

- 2009 ~ 현재 Nutrition Research Associate Editor

- 2007 ~ 2013 Nutrition Research and Practice 편집장

- 2006 ~ 2013 Brain Korea 21 사업팀장

연구 및 저서

- Antika LD, Kim YH, Kang MK, Park SH, Lee EJ, Choi YJ, Kang YH. Dietary compound gossypetin inhibits bone resorption through down-regulating lysosomal cathepsin K activity and autophagy-related protein induction in actin ring-bearing osteoclasts. Journal of Functional Foods, 24(1):390-402, 2016.

- Park SH, Kang MK, Choi YJ, Kim YH, Antika LD, Lim SS, Kang YH. Dietary compound α-asarone alleviates ER stress-mediated apoptosis in 7β-hydroxycholesterol-challenged macrophages. Molecular Nutrition & Food Research, 60(5):1033-1047, 2016.

- Park SH, Gong JH, Choi YJ, Kang MK, Kim YH, Kang YH. Kaempferol inhibits endoplasmic reticulum stress-associated mucus hypersecretion in airway epithelial cells and ovalbumin-sensitized mice. PLoS One, 10(11):e0143526, 2015.

- Kang MK, Park SH, Choi YJ, Shin D, Kang YH. Chrysin inhibits diabetic renal tubulointerstitial fibrosis through blocking epithelial to mesenchymal transition. Journal of Molecular Medicine, 93(7):759-772, 2015.

- Park SH, Shin D, Lim SS, Lee JY, Kang YH. Purple perilla extracts allay ER stress in lipid-laden macrophages. PLoS One, 9(10):e110581, 2014.

- Lee EJ, Kim JL, Kim YH, Kang MK, Gong JH, Kang YH. Phloretin promotes osteoclast apoptosis in murine macrophages and inhibits estrogen deficiency-induced osteoporosis in mice. Phytomedicine, 21(10):1208-1215, 2014.

- Kim YH, Kim JL, Lee EJ, Park SH, Han SY, Kang SA, Kang YH. Fisetin antagonizes cell fusion, cytoskeletal organization and bone resorption in RANKL-differentiated murine macrophages, Journal of Nutritional Biochemistry, 25(3):295-303, 2014.

기타

- 2013 농림축산식품부, 농림축산식품과학기술 농림축산식품부장관상

- 2013 한림대학교 한림학술상

- 2013 한림대학교 업적 종합평가 최우수상/총장상

- 2012 BK21 우수 사업팀, BK21 사업 성과전시회 참여사업팀

- 2010 Nutrilite 학술상

심재훈
  • 분야

    식품미생물 및 발효학

  • 성명

    국문 심재훈

  • 직위

    교수

  • 연구실

    생명과학관 8522-1

  • 연락처

    033-248-2137

  • 이메일

학력

- 서울대학교 식품생명공학과 졸업

- 서울대학교 식품생명공학과 석, 박사

주요경력

- British Columbia University Post-Doc Fellow

- Purdue University Visiting Professor

- 식품의약품안전처 식품위생심의위원 (2020-현재)

- 중소기업기술개발 지원사업 평가위원 (2011-현재)

- 한국산업기술평가관리원, 산업기술혁신 평가단 평가위원 (2011-현재)

- 한국식품영양과학회 편집위원 (2013-현재)

연구 및 저서

- 식품가공저장학 (Food Processing & Preservation) 노봉수외 공저, 2015, 수학사

 

주요 논문

- Jeong, H.M.; Lee, Y.; Shin, Y.J.; Woo, S.H.; Kim, J.S.; Jeong, D.W.; Shin, S.; Jeon, S.H.; Shim, J.H. Development of an enzymatic encapsulation process for a cycloamylose inclusion complex with resveratrol. Food Chem. 2021, 345, 128777.

 

- Woo, S.H.; Kim, J.S.; Jeong, H.M.; Shin, Y.J.; Hong, J.S.; Choi, H.D.; Shim, J.H. Development of freeze-thaw stable starch through enzymatic modification. Foods 2021, 10.

 

- Shin, Y.J.; Woo, S.H.; Jeong, H.M.; Kim, J.S.; Ko, D.S.; Jeong, D.W.; Lee, J.H.; Shim, J.H. Characterization of novel alpha-galactosidase in glycohydrolase family 97 from Bacteroides thetaiotaomicron and its immobilization for industrial application. Int. J. Biol. Macromol. 2020, 152, 727-734.

 

- Koo, Y.S.; Ko, D.S.; Jeong, D.W.; Shim, J.H. Development and application of cyclodextrin hydrolyzing mutant enzyme which hydrolyzes β- and γ‑CD selectively. J. Agric. Food Chem. 2017, 65, 2331-2336.

 

- Kim, N.R.; Jeong, D.W.; Ko, D.S.; Shim, J.H. Characterization of novel thermophilic alpha-glucosidase from Bifidobacterium longum. J. Biol. Macromol. 2017, 99, 594-599.

 

- Choung, W.J.; Hwang, S.H.; Ko, D.S.; Kim, S.B.; Kim, S.H.; Jeon, S.H.; Choi, H.D.; Lim, S.S.; Shim, J.H. Enzymatic synthesis of a novel kaempferol-3-O-beta-d-glucopyranosyl-(1->4)-O-alpha-D-glucopyranoside using cyclodextrin glucanotransferase and its inhibitory effects on aldose reductase, inflammation, and oxidative stress. J. Agric. Food Chem. 2017, 65, 2760-2767.

 

- Lee, H.W.; Jeon, H.Y.; Choi, H.J.; Kim, N.R.; Choung, W.J.; Koo, Y.S.; Ko, D.S.; You, S.; Shim, J.H. Characterization and application of BiLA, a psychrophilic alpha-amylase from Bifidobacterium longum. J. Agric. Food Chem. 2016, 64, 2709-2718.

 

- Jeon, H.Y.; Kim, N.R.; Lee, H.W.; Choi, H.J.; Choung, W.J.; Koo, Y.S.; Ko, D.S.; Shim, J.H. Characterization of a novel maltose-forming alpha-amylase from Lactobacillus plantarum subsp. plantarum ST-III. J. Agric. Food Chem. 2016, 64, 2307-2314.

 

- Koo, Y.S.; Lee, H.W.; Jeon, H.Y.; Choi, H.J.; Choung, W.J.; Shim, J.H. Development and characterization of cyclodextrin glucanotransferase as a maltoheptaose-producing enzyme using site-directed mutagenesis. Protein Eng. Des. Sel. 2015, 28, 531-537.

 

김봉수
  • 분야

    미생물학 (마이크로바이옴)

  • 성명

    국문 김봉수

  • 직위

    부교수

  • 연구실

    생명과학관 8309호

  • 연락처

    033-248-2093

  • 이메일

학력

2001~2007 : 서울대학교 생명과학부 박사 

1997~2001 : 서울대학교 응용생물화학부 학사 
 

주요경력

2020~2022 : 한림대학교 특훈교원

2020~현재 : Appl. Microbiol. 편집위원

2018~현재 : Genes & Genomics 편집위원

2018~현재 : Microbiol. Biotechnol. Letters 편집위원

2016~현재 : J. Microbiol. Biotechnol. 편집위원

2014~현재 : 한림대학교 생명과학과 조교수, 부교수

2011~2014 : (주)천랩 생물정보연구소 연구소장

2008~2011 : 미국 식약청(US F.D.A) 독성학연구소 박사후연구원

2007~2008 : 서울대학교 미생물연구소 박사후연구원

연구 및 저서

연구실 홈페이지 링크

 

■ 논문

<자세한 내용은 연구실 홈페이지 링크 참조>

-Imchang Lee, Debmalya Barh, Olga Podolich, Bertram Brenig, Sandeep Tiwari, Vasco Azevedo, Aristóteles Góes-Neto, Oleg Reva, Natalia Kozyrovska, Jean-Pierre de Vera, Bong-Soo Kim*. (2021) Metagenome-assembled genome sequences obtained from reactivated kombucha microbial community exposed to Mars-like environment outside the international space station. Microbiology Resource Announcements. 10, e00549-21.
- Jaehyun Park, Sharon M. Lutz, Seungil Choi, Sanghun Lee, Sangcheol Park, Kangjin Kim, Hosik Choi, Hansoo Park, So-Yeon Lee, Scott T. Weiss, Soo-Jong Hong, Bong-Soo Kim*, Sungho Won*. (2021) Multi-omics analyses implicate EARS2 in the pathogenesis of atopic dermatitis. Allergy. 76(8); 2602-2604.
- Mi-Jin Kang, So-Yeon Lee, Yoon-Mee Park, Bong-Soo Kim, Min-Jung Lee, Jeong-Hyun Kim, Seonmi Jeong, Seung-Hwa Lee, Min Jee Park, Eun-Sang Rhee, Sungsu Jung, Jisun Yoon, Hyun-Ju Cho, Eun Lee, Song-I Yang, Dong In Suh, Kyung Won Kim, Youn Ho Sheen, Kangmo Ahn, Soo-Jong Hong. (2021) Interaction between IL-17 variants and Streptococcus in the gut contribute to the development of atopic dermatitis in infancy. Allergy Asthma & Immunology Research. 13, 404-419.
- Jin-Jae Lee, Dongeun Yong, Ki Tae Suk, Dong Joon Kim, Heung-Jeong Woo, Seung Soon Lee*, Bong-Soo Kim*. (2021) Alteration of gut microbiota in carbapenem-resistant Enterobacteriaceae carriers during fecal microbiota transplantation according to decolonization periods. Microorganisms. 9, 352.
- Ji Taek Hong, Min-Jung Lee, Sang Jun Yoon, Seok Pyo Shin, Chang Seok Bang, Gwang Ho Baik, Dong Joon Kim, Gi Soo Yoon, Min Jae Shin, Young Lim Ham, Ki Tae Suk*, Bong-Soo Kim*. (2021) Effect of Korean red ginseng on nonalcoholic fatty liver disease: an association of gut microbiota with liver function. Journal of Ginseng Research. 45, 316-324.
- Ji Eun Kim, Hyo-Eun Kim, Hyunjeong Cho, Ji In Park, Min-Jung Kwak, Byung-Yong Kim, Seung Hee Yang, Jung Pyo Lee, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Bong-Soo Kim, Hajeong Lee. (2020) Effect of the similarity of gut microbiota composition between donor and recipient on graft function after living donor kidney transplantation. Scientific Reports. 10, 18881.
- Ji In Park, Tae-Yoon Kim, Bumjo Oh, Hyunjeong Cho, Ji Eun Kim, Seong Ho Yoo, Jung Pyo Lee, Yon Su, Kim, Jongsik Chun, Bong-Soo Kim*, Hajeong Lee*. (2020) Comparative analysis of the tonsillar microbiota in IgA nephropathy and other glomerular diseases. Scientific Reports. 10, 16206.
- Bo Kyoung Hwang, HeyLim Choi, Sang Ho Choi*, Bong-Soo Kim*. (2020) Analysis of microbiota structure and potential functions influencing spoilage of fresh beef meat. Frontiers in Microbiology. 11, 1657.
- Ji Eun Kim, Hyo-Eun Kim, Ji In Park, Hyunjeong Cho, Min-Jung Kwak, Byung-Yong Kim, Seung Gee Yang, Jung Pyo Lee, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Bong-Soo Kim*, Hajeong Lee*. (2020) The association between gut microbiota and uremia of chronic kidney disease. Microorganisms. 8, 907.
- HyeLim Choi, Bo Kyoung Hwang, Bong-Soo Kim*, Sang Ho Choi*. (2020) Influence of pathogen contamination on beef microbiota under different storage temperature. Food Research International. 132, 109-118.
- Yoon Mee Park, So-Yeon Lee, Mi-Jin Kang, Bong-Soo Kim, Min-Jung Lee, Sung Su Jung, Ji Sun Yoon, Hyun-Ju Cho, Eun Lee, Song-I Yang, Ju-Hee Seo, Hyo-Bin Kim, Dong In Suh, Youn Ho Shin, Kyung Won Kim, Kangmo Ahn, Soo-Jong Hong. (2020) Imbalance of gut Streptococcus, Clostridium, and Akkermansia determines the natural course of atopic dermatitis in infant. Allergy Asthma & Immunology Research. 12(2); 322-337.
- Ji-Ung Park, Bumjo Oh, Jung Pyo Lee, Min-Ha Choi, Min-Jung Lee, Bong-Soo Kim*. (2019) Influence of microbiota on diabetic foot wound in comparison with adjacent normal skin based on the clinical features. Biomed Research International. 2019, 7459236.
- Hyo-Eun Kim, Jin-Jae Lee, Min-Jung Lee, Bong-Soo Kim*. (2019) Analysis of microbiome in raw chicken meat from butcher shops and packaged products in South Korea to detect the potential risk of foodborne illness. Food Research International. 122, 517-527.
- Bong-Soo Kim, Chong Won Choi, Hyoseung Shin, Seon-Pil Jin, Jung-Soo Bae, Mira Han, Eun Young Seo, Jongsik Chun, Jin Ho Chung. (2019) Comparison of the gut microbiota of centenarians in longevity villages of South Korea with those of other age groups. Journal of Microbiology and Biotechnology. 29(3); 429-440.
- Jin-Jae Lee, Sae-Hoon Kim, Min-Jung Lee, Byung-Keun Kim, Woo-Jung Song, Heung-Woo Park, Sang-Heon Cho, Soo-Jong Hong, Yoon-Seok Chang*, Bong-Soo Kim*. (2019) Different upper airway microbiome and their functional genes associated with asthma in young adults and elderly individuals. Allergy. 74(4); 709-719.
- Han Young Chung, Byungho Lee, Eun Jung Na, Kyu-Ho Lee, Sangryeol Ryu, Hyungjin Yoon, Ju-Hoon Lee, Hyeun Bum Kim, Heebal Kim, Hee Gon Jeong, Bong-Soo Kim*, Sang Ho Choi*. (2018) Potential survival and pathogenesis of a novel strain, Vibrio parahaemolyticus FORC_022, isolated from a soy sauce marinated crab by genome and transcriptome analyses. Frontiers in Microbiology. 9; 1504.
- Joung-Soo Lim, Seung Hak Yang, Bong-Soo Kim, Eun Young Lee. (2018) Comparison of microbial communities in swine manure at various temperatures and storage times. Asian-Australasian Journal of Animal Sciences. 31(8); 1373-1380.
- Bong-Soo Kim, Dong-Hun Han, Ho Lee, Bumjo Oh. (2018) Association of salivary microbiota with dental caries incidence with dentine involvement after 4 years. Journal of Microbiology and Biotechnology. 28(3); 454-464.
- Min-Jung Lee, Mi-Jin Kang, So-Yeon Lee, Eun Lee, Kangjin Kim, Sungho Won, Dong In Suh, Kyung Won Kim, Young Ho Sheen, Kangmo Ahn, Bong-Soo Kim*, Soo-Jong Hong*. (2018) Perturbation of the gut microbiome genes in infants with atopic dermatitis according to feeding type. Journal of Allergy and Clinical Immunology. 141(4); 1310-1319. <Editors' choice of Issue>, <Selected latest research in AAAAI (American Academy of Allergy Asthma & Immunology)>
- Bong-Soo Kim, Eun Lee, Min-Jung Lee, Mi-Jin Kang, Jisun Yoon, Huyn-Ju Cho, Jaehyun Park, Sungho Won, So Yeon Lee, Soo-Jong Hong. (2018) Different functional genes of upper airway microbiome associated with natural course of childhood asthma. Allergy. 73(3); 644-652.
- Jin Hee Park, Bong-Soo Kim*, Chul-Min Chon. (2018) Characterization of iron and manganese minerals and their associated microbiota in different mine sites to reveal the potential interactions of microbiota with mineral formation. Chemosphere. 191; 245-252.
- Seung-Hak Yang, Hee Kwon Ahn, Bong-Soo Kim, Sun Sik Chang, Ki Yong Chung, Eun Mi Lee, Kwang Seok Ki, Eung Gi Kwon. (2017) Comparison of bacterial communities in leachate from decomposing bovine carcasses. Asian-Australasian Journal of Animal Sciences. 30(11); 1660-1666.
- Tae-Yoon Kim, Jin-Jae Lee, Bong-Soo Kim*, Sang Ho Choi*. (2017) Whole-body microbiota of sea cucumber (Apostichopus japonicas) from South Korea for improved seafood management. Journal of Microbiology and Biotechnology. 27(10); 1753-1762.
- Jin-Jae Lee, Tae-Yoon Kim, Sang Ho Choi, Bong-Soo Kim*. (2017) Analysis of the bacterial microbiome in the small octopus, Octopus variabilis, from South Korea to detect the potential risk of foodborne illness and to improve product management. Food Research International. 102; 51-60.
- Suyeon Kim, Min-Jung Lee, Jin-Jae Lee, Sang Ho Choi, Bong-Soo Kim*. (2017) Analysis of microbiota of the swimming crab (Portunus trituberculatus) in South Korea to identify risk markers for foodborne illness. LWT-Food Science and Technology. 86; 483-491.
- Jing-Hua Wang, Bong-Soo Kim, Kyungsun Han, Hojun Kim. (2017) Ephedra-treated donor-derived gut microbiota transplantation ameliorates high fat diet-induced obesity in rats. International Journal of Environmental Research and Public Health. 14(6); 555.

 

기타

■ 학회활동 
• 한국미생물학회 
• 한국미생물생명공학회 

 

■ 주요 연구주제 
• 인간미생물체 연구 (Human Microbiome)인간의 몸에는 인간 세포와 유전자수보다 훨씬 많고 다양한 미생물들이 존재하고 있습니다. 이 다양한 미생물들의 구성과 역할을 대용량 염기서열 분석 장비인 Next-Generation Sequencer를 활용한 연구 수행을 통해 밝히고자 합니다. 이를 통해 여러 질병과 미생물 군집의 상관성 연구 및 건강 유지를 위한 응용 방안들을 연구합니다. 밝혀낸 다양한 결과를 산업, 보건학 분야에서 활용 가능하도록 합니다. 


• 미생물 메타지노믹스 연구 (Metagenomics)우리 인간을 포함한 지구상의 모든 환경에는 미생물들이 복잡한 구성을 이루며 공존하고 있습니다. 하지만, 대부분의 미생물들은 실험실에서 배양할 수 없는 종들이 대부분입니다. 환경에 실제 존재하는 미생물들의 구성과 생태적 역할을 메타지노믹스를 활용하여 연구를 합니다. 실제 우리가 생활하고 있는 환경의 미생물 군집의 연구 (Household microbiome) 와 여러 환경의 미생물 군집 연구 (Ecosystem microbiome) 결과를 통해 다양한 환경의 관리 방안에 도움을 주고자 합니다. 


• 미생물 유전체 연구 (Genomics)유익한 미생물 종들과 유해한 미생물 종들의 전유전체 (Whole genome) 분석을 통해 이들의 역할과 진화생태적인 상관성을 연구합니다. 연구를 통해 다양한 유전자 검출법과 유전자 활용 기법을 고안하고자 합니다. 

박소현
  • 분야

    보건영양학 (지역사회영양, 영양역학, 영양정책)

  • 성명

    국문 박소현

  • 직위

    조교수

  • 연구실

    생명과학관 8519호

  • 연락처

    033-248-2134

  • 이메일

학력

1998-2002 이화여자대학교 생활과학대학 식품영양학과 [학사]

2003-2005 Tufts University, School of Nutrition Science andPolicy(Food Policy and Applied Nutrition 전공) [석사]

2007-2012 Johns Hopkins University, School ofPublic Health, Department of Internatonal Health(Human Nutrition 전공) [박사] 

주요경력

2002-2003 ㈜매일유업, 홍보팀 사원

2005-2006 한양대학교 의과대학 예방의학교실 연구원

2006-2007 보건복지부 건강기능식품 연구위원 (식품의약품안전청 영양평가팀 근무)

2010-2012 International Food Policy Research Institute, Data Analyst

2012-2014 한양대학교 의과대학 예방의학교실, 건강과 사회 연구소, 박사후 연구원

2014-2016 한양대학교 의과대학 예방의학교실, 건강과 사회 연구소, 연구교수

2012-2015 이화여자대학교, 동덕여자대학교, 고려대학교, 한양대학교 강사 

연구 및 저서

■ 논문
- Park S, KimSA, Kim MK, Cho SH, Choi BY. Trend of the anthropometric indices amongadolescents in an urban and a rural area in Korea over the period of1996-2005.  Korean Journal of Epidemiology 2006; 28(2): 189-198
- Kwon KI, Park S, Lee JH, Kim JY, Yoo KS, Lee JS, Kim SY, Sung HI, Nam HS,Kim JW, Lee HY, Park HK, Kim MC. Prevalence of nutrition labeling and claims onprocessed, and packaged food. Korean JCommunity Nutrition 2007; 12(2) : 206-213
- Kim JY, Lee JH, Park S, Yoo KS, Kwon KI, Lee JS, Kim SY, Sung HI, Nam HS, Kim JW,Lee HY, Park HK, Kim MC. Trans Fat Analysis in Foods.  FoodScience and Industry 2007; 40(1) : 22-26
- Kim JW, Kwon KI, Yoo KS, Park S, Lim CJ, Choi DW. NationalStrategic Planning For Facilitating the Development of New Drugs in the KoreaFood and Drug Administration.  J of the Korean Oil Chemists’ Soc 2008;25(4): 539-555
- Park S, Choi BY, Wang Y, Colantuoni E,Gittelsohn J. School and neighborhood nutrition environment and their association withstudents' nutrition behaviors and weight status in Seoul, South Korea.Journal of Adolescent Health 2013;53(5): 655-662
- ChristiansenK, Qureshi F, Schaible A, Park S,Gittelsohn J. Environmental factors that impact the eating behaviors of low-incomeAfrican American adolescents in Baltimore City. Journalof Nutrition Education and Behavior 2013; 45(6): 652-660
- Park S,Kang JH, Lawrence R, Gittelsohn J. Environmental influences on youth eatinghabits: Insights from parents and teachers in South Korea. Ecology of Food and Nutrition 2014; 5(4):347-362
- Park S, Lee J, KwonKI, Kim J,Byun JE, Kang BW, Choi BY, Park H. Early Adulthood: An Overlooked Age Group inNational Sodium Reduction Initiatives in South Korea. Nutrition Research and Practice 2014;8(6): 719-723 
- Park S, Lee EY, Gittelsohn J, Nkala Denis, ChoiBY. Understanding school health environment through interviews with keystakeholders in Lao PDR, Mongolia, Nepal and Sri Lanka. Health Education and Research 2015; 30(2): 285-297
- Lee J, Park S. Consumer attitudes, barriers,and meal satisfaction associated with sodium-reduced meal intake at worksitecafeterias. Nutrition Research and Practice 2015; 9(6): 644-649
- Lee J, Park S. Management of sodium-reducedmeals at worksite cafeterias: Perceptions, practices, barriers, and needs amongfood service personnel. Osong Public Health Research Perspectives 2016;7(2):119-126
- Park S, Lee J.“When operating a cafeteria, sales come before nutrition” - Finding barriers and facilitators toserving reduced-sodium meals in worksite cafeterias. Public Health Nutrition Sep 2015. Epubahead of publication.
- Gittelsohn J, Park S. “Schooland Community-Based Interventions,” in Pediatric Obesity: Etiology,Pathogenesis and Treatment (Freemark M, editor); Humana Press: New York,pp. 315-336.

 

박경호
  • 분야

    의학영양학

  • 성명

    국문 박경호

  • 직위

    조교수

  • 연구실

    생명과학관 8515호

  • 연락처

    033-248-2131

  • 이메일

학력

2003: 경희대학교 학사

2005: 경희대학교 동서의학대학원 석사

2009: 경희대학교 동서의학대학원 박사

주요경력

2020 ~ 현재: 래스 주식회사(교원 창업) 대표이사

2017 ~ 현재: 미래융합스쿨 의약신소재전공 겸임조교수

2014 ~ 2017: 미국 UCSF 산하 NCIRE-VA Medical Center 피부과 조교수(연구)

2009 ~ 2014: 미국 UCSF 피부과 박사후연구원 & 선임연구원

연구 및 저서

연구 분야

- 스핑고지질 대사체 중심의 질환(피부 & 암) 기전 연구 및 치료제 개발

- 피부장벽기능의 이해: 영양학적 접근

- 물질 분석 및 분석법 개발

 

주요 논문

1. Shin KO et al., Activation of SIRT1 enhances epidermal permeability barrier formation through ceramide synthase 2- and 3-dependent mechanisms. J Invest Dermatol 40:1435-1438, 2020

2. Lee J et al., Cathelicidin-related antimicrobial peptide regulates CD73 expression in mouse Th17 Cells via p38. Cells 9:1561, 2020

3. Shin KO et al., Both sphingosine kinase 1 and 2 coordinately regulate cathelicidin antimicrobial peptide production during keratinocyte differentiation. J Invest Dermatol 139:492-494, 2019

4. Park K et al., ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. PNAS 113: E1334-42, 2016 (Note: This article was featured in Cell Chemical Biology 23(3): 313-314, 2016)

5. Park K et al., Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway. J Biol Chem 286: 34121-30, 2011


See more contributions to science: https://pubmed.ncbi.nlm.nih.gov/?term=kyungho+park&sort=date

기타

■ 수상

2014 미국피부과학회/일본피부과학회 Junior Faculty Award

2014 미국피부과학회 Research Fellow Award

2011 제6회 국제 세라마이드학회 Speaker Award

 

■ 홈페이지

www.phdlass.com