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강영희
  • 분야

    영양생리학

  • 성명

    국문 강영희

  • 직위

    석좌교수

  • 연구실

    생명과학관 8617호

  • 연락처

    033-248-2132

  • 이메일

학력

- 1981 서울대학교 학사

- 1983 Drexel University 석사

- 1988 Rutgers University 박사

주요경력

- 2018. 9. 1 ~ 현재 : 식품영양학과장

- 2015 ~ 현재 한국과학기술한림원 농수산학부 정회원

- 2013 ~ 2015 한림대학교 교무처장

- 2013 ~ 2015 식품영양학과 BK21 plus 사업팀장

- 2013 ~ 2013 한림대학교 자연과학대학 학장

- 2009 ~ 현재 Nutrition Research Associate Editor

- 2007 ~ 2013 Nutrition Research and Practice 편집장

- 2006 ~ 2013 Brain Korea 21 사업팀장

연구 및 저서

- Antika LD, Kim YH, Kang MK, Park SH, Lee EJ, Choi YJ, Kang YH. Dietary compound gossypetin inhibits bone resorption through down-regulating lysosomal cathepsin K activity and autophagy-related protein induction in actin ring-bearing osteoclasts. Journal of Functional Foods, 24(1):390-402, 2016.

- Park SH, Kang MK, Choi YJ, Kim YH, Antika LD, Lim SS, Kang YH. Dietary compound α-asarone alleviates ER stress-mediated apoptosis in 7β-hydroxycholesterol-challenged macrophages. Molecular Nutrition & Food Research, 60(5):1033-1047, 2016.

- Park SH, Gong JH, Choi YJ, Kang MK, Kim YH, Kang YH. Kaempferol inhibits endoplasmic reticulum stress-associated mucus hypersecretion in airway epithelial cells and ovalbumin-sensitized mice. PLoS One, 10(11):e0143526, 2015.

- Kang MK, Park SH, Choi YJ, Shin D, Kang YH. Chrysin inhibits diabetic renal tubulointerstitial fibrosis through blocking epithelial to mesenchymal transition. Journal of Molecular Medicine, 93(7):759-772, 2015.

- Park SH, Shin D, Lim SS, Lee JY, Kang YH. Purple perilla extracts allay ER stress in lipid-laden macrophages. PLoS One, 9(10):e110581, 2014.

- Lee EJ, Kim JL, Kim YH, Kang MK, Gong JH, Kang YH. Phloretin promotes osteoclast apoptosis in murine macrophages and inhibits estrogen deficiency-induced osteoporosis in mice. Phytomedicine, 21(10):1208-1215, 2014.

- Kim YH, Kim JL, Lee EJ, Park SH, Han SY, Kang SA, Kang YH. Fisetin antagonizes cell fusion, cytoskeletal organization and bone resorption in RANKL-differentiated murine macrophages, Journal of Nutritional Biochemistry, 25(3):295-303, 2014.

기타

- 2013 농림축산식품부, 농림축산식품과학기술 농림축산식품부장관상

- 2013 한림대학교 한림학술상

- 2013 한림대학교 업적 종합평가 최우수상/총장상

- 2012 BK21 우수 사업팀, BK21 사업 성과전시회 참여사업팀

- 2010 Nutrilite 학술상

강일준
  • 분야

    식품학 (건강기능식품, 식품위생/안전, 영양생화학)

  • 성명

    국문 강일준

  • 직위

    교수

  • 연구실

    생명과학관 8509호

  • 연락처

    033-248-2135 또는 3305

  • 이메일

학력

1989~1992 교토대학교(박사-식품공학과)

1986~1988 고려대학교(석사-식품공학과)

1982~1986 고려대학교(학사-식품공학과)

주요경력

교내 경력:
2021~현재 산학 부총장
2021~현재 산학협력단장
2021~현재 LINC+사업단장
2020~2021 헬스케어소재 센터장
2013~2020 한국영양연구 소장
2019~2020 지역전략산업혁신 센터장
2018~2019 지역혁신 센터장
2016~2018 자연과학대 학장
2012~2013 한림대학교 기획처장

 

교외경력:
2021.01~현재 국무조정실 제7기 식품안전정책위원회 가공수입식품 분과위원장
2021.05~현재 식약처 식품안전정책위원회 전문위원
2021.05~현재 한국소비자연맹 식의약안전포럼 전문위원
2020.10~현재 식약처 정책자문위원회 위원(20.10~)
2020.07~현재 기획재정부 재정사업평가위원회 위원
2020.06~현재 식약처 규제입증위원회 위원
2020.05~현재 한국과학기술단체총연합회 이사
2020.05~현재 식약처 건강기능식품심의위원회 위원장
2020.01~현재 한국건강기능식품협회 표시·광고 자율심의위원회 위원장
2021 한국식품영양과학회 이사/발전위원회 위원장
2020 한국식품영양과학회 회장
2019.11~현재 한국연구재단 기초연구본부 생명과학단 책임전문위원(CRB)
2019.01~현재 인제군 어린이급식관리지원센터 센터장
2019.06~현재 식약처 식품·의약품 안전기술위원회 위원
2019.04~2021.4 한국식품안전관리인증원 이사
2018.03~현재 국민청원안전검사 심의위원회 위원
2015~2018 식품의약품안전처 어린이기호식품 품질인증 심사반 위원
2014~2016 기획재정부 공공기관 경영평가단 위원
2012.07~현재 교육부 산업단지캠퍼스 설립심사위원회 위원

연구 및 저서

주요 논문
Increased Calbindin D28k Expression via Long-Term Alternate-Day Fasting Does Not Protect against Ischemia-Reperfusion Injury: A Focus on Delayed Neuronal Death, Gliosis and Immunoglobulin G Leakage. Int. J. Mol. Sci. 22, 644 (2021)

Aesculetin Inhibits Airway Thickening and Mucus Overproduction Induced by Urban Particulate Matter through Blocking Inflammation and Oxidative Stress Involving TLR4 and EGFR. Antioxidants, 10, 494 (2021) 

Therapeutic Effects of Decursin and Angelica gigas Nakai Root Extract in Gerbil Brain after Transient Ischemia via Protecting BBB Leakage and Astrocyte Endfeet Damage. Molecules, 26, 2161 (2021)

Astragalin Inhibits Cigarette Smoke-Induced Pulmonary Thrombosis and Alveolar Inflammation and Disrupts PAR Activation and Oxidative Stress-Responsive MAPK-Signaling. Int. J. Mol. Sci. 22, 3692 (2021)

Anti-Obesity Effect of Erigeron annuus (L.) Pers. Extract Containing Phenolic Acids. Foods, 10, 1266 (2021)

Populus tomentiglandulosa Extract Is Rich in Polyphenols and Protects Neurons, Astrocytes, and the Blood-Brain Barrier in Gerbil Striatum Following Ischemia-Reperfusion Injury. Molecules, 26, 5430 (2021)

Aesculetin Accelerates Osteoblast Differentiation and Matrix-Vesicle-Mediated Mineralization Int. J. Mol. Sci. 22, 12391 (2021)

Ischemia-Induced Cognitive Impairment Is Improved via Remyelination and Restoration of Synaptic Density in the Hippocampus after Treatment with COG-Up® in a Gerbil Model of Ischemic Stroke. Vet. Sci. 8, 321 (2021)

Pre-Treatment with Laminarin Protects Hippocampal CA1 Pyramidal Neurons and Attenuates Reactive Gliosis Following Transient Forebrain Ischemia in Gerbils. Mar. Drugs. 2020, 18, 52 (2020)

A Combination of Korean Red Ginseng Extract and Glycyrrhiza glabra L. Extract Enhances Their Individual Anti-Obesity Properties in 3T3-L1 Adipocytes and C57BL/6J Obese Mice. J Med Food. 23(3), 215–223 (2020)

Preclinical Research on a Mixture of Red Ginseng and Licorice Extracts in the Treatment and Prevention of Obesity, Nutrients, 12(9), 2744 (2020)

Experimental Pretreatment with Chlorogenic Acid Prevents Transient Ischemia-Induced Cognitive Decline and Neuronal Damage in the Hippocampus through Anti-Oxidative and Anti-Inflammatory Effects, Molecules, 25, 3578 (2020)

Pretreated Oenanthe Javanica extract increases anti-inflammatory cytokines, attenuates gliosis, and protects hippocampal neurons following transient global cerebral ischemia in gerbils. Neural Regen Res. 14(9):1536-1543 (2019)

Protective Effects and Mechanisms of Pourthiaea villosa (Thunb.) Decne. Extract on Hydrogen Peroxide-Induced Skin Aging in Human Dermal Fibroblasts, J Med Food. 22 (8), 841–850 (2019) 

Anti-Obesity Effect of Extract from Nelumbo Nucifera L., Morus Alba L., and Raphanus Sativus Mixture in 3T3-L1 Adipocytes and C57BL/6J Obese Mice, Foods, 8(5), (2019)

Erigeron annuus (L.) Pers. Extract Inhibits Reactive Oxygen Species (ROS) Production and Fat Accumulation in 3T3-L1 Cells by Activating an AMP-Dependent Kinase Signaling Pathway, Antioxidants(Basel). 8(5), (2019)

Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions, Chin J Nat Med. 17(6): 424-434 (2019)

Melatonin alleviates asphyxial cardiac arrest-induced cerebellar Purkinje cell death by attenuation of oxidative stress, Exp Neurol. 320:112983 (2019)

Synergistic action of Erigeron annuus L. Pers and Borago officinalis L. enhances anti-obesity activity in a mouse model of diet-induced obesity. Nutr Res. 69: 58 (2019)

Down-regulation of cyclin-dependent kinase 5 attenuates p53-dependent apoptosis of hippocampal CA1 pyramidal neurons following transient cerebral ischemia, 
Sci Rep. 9(1):13032 (2019)

A 2-Min Transient Ischemia Confers Cerebral Ischemic Tolerance in Non-Obese Gerbils, but Results in Neuronal Death in Obese Gerbils by Increasing Abnormal mTOR Activation-Mediated Oxidative Stress and Neuroinflammation, Cells, 8(10) (2019)

 

저서

식품학개론, 라이프사이언스, 2021

식품화학 길라잡이, 라이프사이언스, 2015

식품저장학, 고려대학교출판부, 2012

재미있는 식품화학, 수학사 , 2011

생화학, 녹문당, 2008

기타

특허

두메부추 및 오이풀 추출물의 제조방법 및 상기 추출물을 유효성분으로 포함하는 비만 및 비만으로부터 유도된 대사증후군 개선용 조성물(제10-2200260-0000, 2021)

퀘르시트린과 스피레오시드 그리고 이들의 혼합물을 유효성분으로 포함하는 비만 개선, 예방 또는 치료용 조성물(제10-2007465-0000, 2019) 

현사시나무 추출물을 유효성분으로 함유하는 허혈성 뇌혈관 질환 예방용 조성물 (제10-1852583-0000, 2018)

유산균(Lactobacillus rhamnosus HK-9) 발효 길경추출물을 유효성분으로 포함하는 비만 개선 및 치료용 조성물 (제10-1781186-0000, 2017)

오이풀 추출물을 유효성분으로 포함하는 당뇨 및 당뇨합병증 예방 또는 개선용 조성물 (제10-1737854-0000, 2017)

 

수상

근정포장(2019.05)

대통령 표창 (2010.05)

한국연구재단이사장 표창(2021.06)

제21회 오뚜기 함태호 학술상(2019.10)

제26회 과학기술 우수논문상(2016.07)

강원지방중소기업청장 표창(2015.12)

뉴트리라이트 학술상 수상(2013.11)

강원도지사 표창(2011.12)

임순성
  • 분야

    천연물연구

  • 성명

    국문 임순성

  • 직위

    교수

  • 연구실

    천연물화학(8510호)

  • 연락처

    033-248-2133

  • 이메일

학력

1986 ~ 1990 고려대학교 화학전공(학사)

1990 ~ 1994 고려대학교 유기화학전공(석사)

1995 ~ 2000 고려대학교 유기화학전공(박사)

 

주요경력

2008.03 ~ 한림대학교 자연과학대 식품영양학과(교수)
2003.04 ~ 2008.02 한림대학교 RRC-RIC(연구교수)
2001.12 ~ 2003.01 스위스 로잔대 IPP(박사후 연수)
2001.02 ~ 2001.11 서울대학교(박사후 연수)
2000.12 ~ 2001.01 일본 동북대(객원연구원)
1994.09 ~ 2000.08 서울대학교 천연물과학연구소 조교(연구원)
1992.09 ~ 2003.08 고려대학교 화학과(조교 및 시간강사) 

연구 및 저서

■ 천연물연구
- UPLC, MPLC, HSCCC 및 open column chromatography를 이용한 천연물로부터 유효물질의 분리/정제/구조결정
- 신규 On-line bioassay 및 enzyme binding assay (UF)를 활용하여 신속한 생리활성 물질의 검색
- 반응표면분석법 (RSM)을 이용한 최적화 추출공정 개발 및 Scale up 공정 연구
- CYP450 효소를 이용한 천연물과 의약품간의 약물상호작용 (Drug-Drug Interaction, DDI) 연구
- 천연물의 생물전환(biotransformation) 대사체 연구 (PCA & Metabolites)
- 유효물질을 기반으로 한 흡수증대를 갖는 제형 개발 (Solubility, PAMPA 개선)
- 효소합성법 (Enzymatic synthesis method)를 이용한 폴리페놀 유도체의 친환경 합성법 개발

 

■ 주요 연구 천연물
- 감초/단삼/짚신나물/미역취/차즈기/멀꿀나무/다릅나무/털장구채/산옥잠화/쥐오줌풀/곤충 효소 가수분해물 (yellow worm)/천마/MACA의 생리활성 성분의 구조규명 연구 및 원료표준화 (CMC) 연구

 

■ 기능성(생리활성) 연구 분야
- 당뇨 및 당뇨합병증 치료소재 개발 (합성화합물 포함한 천연물소재)
- 개별인정형 건강기능식품 소재 개발 (식후혈당, 체지방감소, 뼈/관절 건강, 혈중중성지방개선)
- 천연물로부터 기능성화장품 소재 개발 (미백/주름/자외선차단/탈모방지)
- 천연물 유효물질의 합성유도체로부터 통증 치료 소재
-  암세포 특이적 세포사 물질(합성신약) 연구

기타

■ 논문 
1. Ischemia-Induced Cognitive Impairment Is Improved via Remyelination and Restoration of Synaptic Density in the Hippocampus after Treatment with COG-Up® in a Gerbil Model of Ischemic Stroke. Veterinary Sciences 8 (12), 321 (2021)
2. Asaronic acid inhibits ER stress sensors and boosts functionality of ubiquitin-proteasomal degradation in 7β-hydroxycholesterol-loaded macrophages. Phytomedicine 92, 153763 (2021)
3. Purple corn extract alleviates 2, 4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice. Animal cells and systems 25 (5), 272-282 (2021)
4. Extracts from the Leaves of Cissus verticillata Ameliorate High-Fat Diet-Induced Memory Deficits in Mice. Plants 10 (9), 1814 (2021)
5. Separation and Identification of Antioxidants and Aldose Reductase Inhibitors in Lepechinia meyenii (Walp.) Epling (2021) 
6. Metformin‑induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells. Scientific Reports 11 (1), 1-13 (2021)
7. The  Anti-Inflammatory and  the Antinociceptive Effects of Mixed Agrimonia pilosa Ledeb.  and Salvia miltiorrhiza Bunge  Extract. Plants 10 (6), 1234 (2021)
8. Cissus verticillata Extract Decreases Neuronal Damage Induced by Oxidative Stress in HT22 Cells and Ischemia in Gerbils by Reducing the Inflammation and Phosphorylation of MAPKs. Plants 10 (6), 1217 (2021)
9. Defatted Seeds of Oenothera biennis as a Potential Functional Food Ingredient for Diabetes. Foods 10 (3), 538 (2021)
10.  Purple corn extract (PCE) alleviates cigarette smoke (CS)-induced DNA damage in rodent blood cells by activation of AMPK/Foxo3a/MnSOD pathway. Animal Cells and Systems 25 (1), 65-73 (2021)
11.  Valeriana rigida Ruiz & Pav. Root Extract: A New Source of Caffeoylquinic Acids with Antioxidant and Aldose Reductase Inhibitory Activitie. Foods 10 (5), 1079 (2021)
12.  Effect of Extract and Synthesized Derivatives of Isolated Compound from Symplocos chinensis f. Pilosa Ohwi on Neuropathic Pain in Mice. Molecules 26 (6), 1639 (2021)
13.  Increased Calbindin D28k Expression  via Long-Term Alternate-Day  Fasting  Does  Not  Protect against Ischemia-Reperfusion Injury:  A  Focus on Delayed Neuronal Death,  Gliosis and Immunoglobulin G Leakage. International Journal of Molecular Sciences 22 (2), 644 (2021)
14.  Chemical Composition of a Novel Distillate from Fermented Mixture of Nine Anti-Inflammatory Herbs and Its UVB-Protective Efficacy in Mouse Dorsal Skin via Attenuating Collagen Disruption and Inflammation. Molecules 26 (1), 124 (2021)
15.  Efficient Separation of Phytochemicals from Muehlenbeckia volcanica (Benth.) Endl. by Polarity-Stepwise Elution Counter-Current Chromatography and Their Antioxidant, Antiglycation, and Aldose Reductase Inhibition Potentials. Molecules 26 (1), 224 (2021)
16.  Licochalcone A inhibits hypoxia-inducible factor-1α accumulation by suppressing mitochondrial respiration in hypoxic cancer cells. Biomedicine & Pharmacotherapy 133, 111082 (2021)
17.  Linarin and its aglycone acacetin abrogate actin ring formation and focal contact to bone matrix of bone-resorbing osteoclasts through inhibition of alpha v beta 3 integrin and core-linked CD44. PHYTOMEDICINE (2020)
18.  Constituents from Solidago virgaurea var. gigantea and their inhibitory effect on lipid accumulation. FITOTERAPIA (2020)
19.  Retention mechanism of pH-peak-focusing in countercurrent chromatographic separation of baicalin and wogonoside from Scutellaria baicalensis Georgi. JOURNAL OF SEPARATION SCIENCE (2020)
20.  An Off-Line DPPH-GC-MS Coupling Countercurrent Chromatography Method for Screening, Identification, and Separation of Antioxidant Compounds in Essential Oil. ANTIOXIDANTS (2020)
21.  Asaronic Acid Inhibited Glucose-Triggered M2-Phenotype Shift Through Disrupting the Formation of Coordinated Signaling of IL-4R alpha-Tyk2-STAT6 and GLUT1-Akt-mTOR-AMPK. NUTRIENTS (2020)
22.  Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice. FOOD SCIENCE  NUTRITION (2020)
23.  Anti-obesity effect of Melandrium firmum Rohrbach extract in 3T3-L1 cells and high-fat diet-induced obese C57BL/6N mice. FOOD SCIENCE  NUTRITION (2020)
24.  Antinociceptive effect of chrysin in diabetic neuropathy and formalin-induced pain models. ANIMAL CELLS AND SYSTEMS (2020)
25.  Discovery of Epinastine-NSAID Hybrids as Potential Anti-inflammatory Agents: Synthesis and In Vitro Nitric Oxide Production Inhibitory Activity Study (2020)
26.  Melandrium firmum Extract Promotes Hair Growth by Modulating 5 alpha-Reductase Activity and Gene Expression in C57BL/6J Mice. ANNALS OF DERMATOLOGY (2019)
27.  Affinity measurement of ligands in Perilla frutescens extract towards alpha-glucosidase using affinity-based ultrafiltration-high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2019)
28.  Antinociceptive effect of single components isolated from Agrimonia pilosa ledeb. Extract. Scientia Pharmaceutica (2019)
29.  Asaronic Acid Attenuates Macrophage Activation toward M1 Phenotype through Inhibition of NF-kappa B Pathway and JAK-STAT Signaling in Glucose-Loaded Murine Macrophages. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)
30.  Liposomal formulation and pharmacokinetic study of CPD409, a novel sodium channel blocker. Journal of Pharmaceutical Investigation. Journal of Pharmaceutical Investigation (2019)
31.  Effects of resveratrol and oxyresveratrol on hippocampal cell death induced by kainic acid. ANIMAL CELLS AND SYSTEMS (2019)
32.  Target guided isolation of potential tyrosinase inhibitors from Otholobium pubescens (Poir.) JW Grimes by ultrafiltration, high-speed countercurrent chromatography and preparative HPLC. INDUSTRIAL CROPS AND PRODUCTS (2019)
33.  Fermented dried Citrus unshiu peel extracts exert anti-inflammatory activities in LPS-induced RAW264.7 macrophages and improve skin moisturizing efficacy in immortalized human HaCaT keratinocytes. PHARMACEUTICAL BIOLOGY (2019)
34.  Aldose Reductase, Protein Glycation Inhibitory and Antioxidant of Peruvian Medicinal Plants: The Case of Tanacetum parthenium L. and Its Constituents. MOLECULES (2019)
35.  Chemical Compositions of the Volatile Oils and Antibacterial Screening of Solvent Extract from Downy Lavender. FOODS (2019)
36.  Novel aldose reductase inhibitory and antioxidant chlorogenic acid derivatives obtained by heat treatment of chlorogenic acid and amino acids. Food Chemistry (2018)
37.  Lipid-Lowering Effects of Medium-Chain Triglyceride-Enriched Coconut Oil in Combination with Licorice Extracts in Experimental Hyperlipidemic Mice. Journal of Agricultural and Food Chemistry (2018)
38.  Pistafolin B is the major aldose reductase inhibitor of the pods of tara [Caesalpinia spinose (Molina) Kuntze] Industrial Crops and Products (2018)
39.  Anti-Nociceptive Effect and Standardization from Mixture of Agrimonia pilosa Ledeb and Salvia miltiorrhiza Bunge Extracts. Journal of Medicinal Food (2018)
40.  Antioxidant activity and inhibitory effects of 2-hydroxy-3-methylcyclopent-2-enone isolated from ribose-histidine Maillard reaction products on aldose reductase and tyrosinase. Food and Function (2018)
41.  An: In vitro affinity-based method for studying herb-drug interactions for direct identification of cytochrome P450 1A2, 3A4, and 2C9 specific ligands from herbal extracts using ultrafiltration-high performance liquid chromatography. RSC Advances (2018)
42.  Anti-glycation, carbonyl trapping and anti-inflammatory activities of chrysin derivatives. Molecules (2018) 
43.  Antiobesity Effect of Astilbe chinensis Franch. et Savet. Extract through Regulation of Adipogenesis and AMP-Activated Protein Kinase Pathways in 3T3-L1 Adipocyte and High-Fat Diet-Induced C57BL/6N Obese Mice. Evidence-based Complementary and Alternative Medicine (2018)
44.  Evaluation of aldose reductase, protein glycation, and antioxidant inhibitory activities of bioactive flavonoids in Matricaria recutita L. and their structure-activity relationship. Journal of Diabetes Research (2018)
45.  Screening In Vitro Targets Related to Diabetes in Herbal Extracts from Peru: Identification of Active Compounds in Hypericum laricifolium Juss. by Offline High-Performance Liquid Chromatography. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
46.  Characterization of DHDP, a novel aldose reductase inhibitor isolated from Lysimachia christinae. JOURNAL OF FUNCTIONAL FOODS (2017)
47.  Anti-Obesity Effect of the Above-Ground Part of Valeriana dageletiana Nakai ex F. Maek Extract in High-Fat Diet-Induced Obese C57BL/6N Mice. NUTRIENTS (2017)
48.  Protein Tyrosine Phosphatase 1β (PTP1β) Inhibitory Compounds Isolated from Prunella vulgaris. Chemistry of Natural Compounds (2017)
49.  Alantolactone and Isoalantolactone Prevent Amyloid β(25-35)-induced Toxicity in Mouse Cortical Neurons and Scopolamine-induced Cognitive Impairment in Mice. PHYTOTHERAPY RESEARCH (2017)
50.  Bioactivity-guided isolation and identification of anti-adipogenic compounds from Sanguisorba officinalis L. FASEB JOURNAL (2017)
51.  Screening of Peruvian Medicinal Plants for Tyrosinase Inhibitory Properties: Identification of Tyrosinase Inhibitors in Hypericum laricifolium Juss. MOLECULES (2017)
52.  Phytochemical Analysis of Agrimonia pilosa Ledeb, Its Antioxidant Activity and Aldose Reductase Inhibitory Potential. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
53.  Rapid High Performance Liquid Chromatography Determination and Optimization of Extraction Parameters of the -Asarone Isolated from Perilla frutescens L. MOLECULES (2017)
54.  Analytical Method for the Validation of Three Polyphenols as a Marker Compound for the Standardization of Solidago virgaurea subsp gigantea Extracts and Antiadipogenesis of Harvesting Time and Location. JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY (2017)
55.  Anti-obesity effect of Solidago virgaurea var. gigantea extract through regulation of adipogenesis and lipogenesis pathways in high-fat diet-induced obese mice (C57BL/6N) FOOD  NUTRITION RESEARCH (2017)
56.  Antidiabetic Effect of Fresh Nopal (Opuntia ficus-indica) in Low-Dose Streptozotocin-Induced Diabetic Rats Fed a High-Fat Diet. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)
57.  Chemo-enzymatic synthesis of vinyl and L-ascorbyl phenolates and their inhibitory effects on advanced glycation end products. FOOD CHEMISTRY (2017)
58.  Competitive binding experiments can reduce the false positive results of affinity-based ultrafiltration-HPLC: A case study for identification of potent xanthine oxidase inhibitors from Perilla frutescens extract. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2017)
59.  Comprehensive evaluation of the antioxidant capacity of Perilla frutescens leaves extract and isolation of free radical scavengers using step-wise HSCCC guided by DPPH-HPLC. INTERNATIONAL JOURNAL OF FOOD PROPERTIES (2017)
60.  Comprehensive profiling of minor tyrosinase inhibitors from Gastrodia elata using an off-line hyphenation of ultrafiltration, high-speed countercurrent chromatography, and high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY A (2017)
61.  Enzymatic Synthesis of a Novel Kaempferol-3-O-beta-D-glucopyranosyl(1 -> 4)-O-alpha-D-glucopyranoside Using Cyclodextrin Glucanotransferase and Its Inhibitory Effects on Aldose Reductase, Inflammation, and Oxidative Stress. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)
62.  Inhibitory Activities of Stauntonia hexaphylla Leaf Constituents on Rat Lens Aldose Reductase and Formation of Advanced Glycation End Products and Antioxidant. BIOMED RESEARCH INTERNATIONAL (2017)
63.  Investigation of the antioxidant and aldose reductase inhibitory activities of extracts from Peruvian tea plant infusions. FOOD CHEMISTRY (2017)
64.  Rapid Identification and Isolation of Inhibitors of Rat Lens Aldose Reductase and Antioxidant in Maackia amurensis. BIOMED RESEARCH INTERNATIONAL (2017)
65.  Synergetic hepatoprotective effects of korean red ginseng and pueraria radix on the liver damaged-induced by carbon tetrachloride (CCL4) in mice. Natural Product Sciences (2017)
66.  alpha-Asarone blocks 7 beta-hydroxycholesterol-exposed macrophage injury through blocking elF2 alpha phosphorylation and prompting beclin-1-dependent autophagy. ONCOTARGET (2017) 


■ 주요 특허 등록 
1. 코르너스 오블롱가 추출물을 이용한 항염증용 조성물, 제10-2226439-0000, 2021
2. 코르너스 오블롱가 추출물을 이용한 궤양성 대장염 개선용 조성물, 제10-2226448-0000, 2021
3. 유통기한이 향상되고 오메가-3가 증가된 생들기름 제조방법, 제10-2249821-0000, 2021
4. 노루궁뎅이버섯 가수분해물을 유효성분으로 포함하는 항산화 및 항비만 조성물, 제10-2144513-0000, 2020
5. 로로통 추출물을 유효성분으로 함유하는 통증 예방 또는 치료용 조성물, 제10-2109498-0000, 2020
6. 소목(Caesalpinia eriostachys Benth) 추출물을 유효성분으로 함유하는 통증 예방 또는 치료용 조성물, 제10-2088768-0000, 2020
7. Combretum farinosum Kunth 추출물을 유효성분으로 함유하는 통증 예방 또는 치료용 조성물, 제10-2073796-0000, 2020
8. 신규한 크리신 유도체 화합물을 유효성분으로 포함하는 당뇨합병증의 예방 또는 치료용 약학 조성물, 제10-2032739-0000, 2019
9. 짚신나물 및 단삼의 추출물을 유효성분으로 포함하는 조성물 및 이의 제조방법, 제10-2009669-0000, 2019
10. 사이클로덱스트린 글루카노트랜스퍼레이즈를 이용한 수용성이 증대된 아스트라갈린의 당전이 화합물의 제조방법 및 이로부터 제조된 아스트라갈린의 당전이 화합물을 함유하는 조성물, 제10-1986789-0000, 2019
11. 코코넛 오일의 상온 유동성 개선방법, 제10-1978158-0000, 2019
12. 미역취 추출물을 함유하는 항비만 식품 조성물 및 이의 제조방법, 제10-1952257-0000, 2019
13. 짚신나물 및 단삼의 추출물을 유효성분으로 포함하는 조성물 및 이의 제조방법, 제10-1952242-0000, 2019
14. 멀꿀 나무 추출물을 함유하는 당뇨합병증의 예방 또는 치료용 약학 조성물, 제10-1883870-0000, 2018
15. 페루산 포라덴드론 콰드랭귤러 식물 추출물을 함유하는 당뇨합병증의 예방 또는 치료용, 제10-1880164-0000, 2018
16. 야관문 추출물을 유효성분으로 포함하는 피부미백용 조성물, 제10-1876319-0000, 2018
17. 5원 헤테로사이클릭 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물, 제10-1844984-0000, 2018
18. 미역취 추출물을 함유하는 항비만 식품 조성물 및 이의 제조방법, 제10-1754149-0000, 2017
19. 차즈기 추출물을 포함하는 콜레스테롤 대사 관련 혈관질환 개선용 식품 조성물 및 이의 제조방법, 제10-1733048-0000, 2017

심재훈
  • 분야

    식품미생물 및 발효학

  • 성명

    국문 심재훈

  • 직위

    교수

  • 연구실

    생명과학관 8522-1

  • 연락처

    033-248-2137

  • 이메일

학력

- 서울대학교 식품생명공학과 졸업

- 서울대학교 식품생명공학과 석, 박사

주요경력

- British Columbia University Post-Doc Fellow

- Purdue University Visiting Professor

- 식품의약품안전처 식품위생심의위원 (2020-현재)

- 중소기업기술개발 지원사업 평가위원 (2011-현재)

- 한국산업기술평가관리원, 산업기술혁신 평가단 평가위원 (2011-현재)

- 한국식품영양과학회 편집위원 (2013-현재)

연구 및 저서

- 식품가공저장학 (Food Processing & Preservation) 노봉수외 공저, 2015, 수학사

 

주요 논문

- Jeong, H.M.; Lee, Y.; Shin, Y.J.; Woo, S.H.; Kim, J.S.; Jeong, D.W.; Shin, S.; Jeon, S.H.; Shim, J.H. Development of an enzymatic encapsulation process for a cycloamylose inclusion complex with resveratrol. Food Chem. 2021, 345, 128777.

 

- Woo, S.H.; Kim, J.S.; Jeong, H.M.; Shin, Y.J.; Hong, J.S.; Choi, H.D.; Shim, J.H. Development of freeze-thaw stable starch through enzymatic modification. Foods 2021, 10.

 

- Shin, Y.J.; Woo, S.H.; Jeong, H.M.; Kim, J.S.; Ko, D.S.; Jeong, D.W.; Lee, J.H.; Shim, J.H. Characterization of novel alpha-galactosidase in glycohydrolase family 97 from Bacteroides thetaiotaomicron and its immobilization for industrial application. Int. J. Biol. Macromol. 2020, 152, 727-734.

 

- Koo, Y.S.; Ko, D.S.; Jeong, D.W.; Shim, J.H. Development and application of cyclodextrin hydrolyzing mutant enzyme which hydrolyzes β- and γ‑CD selectively. J. Agric. Food Chem. 2017, 65, 2331-2336.

 

- Kim, N.R.; Jeong, D.W.; Ko, D.S.; Shim, J.H. Characterization of novel thermophilic alpha-glucosidase from Bifidobacterium longum. J. Biol. Macromol. 2017, 99, 594-599.

 

- Choung, W.J.; Hwang, S.H.; Ko, D.S.; Kim, S.B.; Kim, S.H.; Jeon, S.H.; Choi, H.D.; Lim, S.S.; Shim, J.H. Enzymatic synthesis of a novel kaempferol-3-O-beta-d-glucopyranosyl-(1->4)-O-alpha-D-glucopyranoside using cyclodextrin glucanotransferase and its inhibitory effects on aldose reductase, inflammation, and oxidative stress. J. Agric. Food Chem. 2017, 65, 2760-2767.

 

- Lee, H.W.; Jeon, H.Y.; Choi, H.J.; Kim, N.R.; Choung, W.J.; Koo, Y.S.; Ko, D.S.; You, S.; Shim, J.H. Characterization and application of BiLA, a psychrophilic alpha-amylase from Bifidobacterium longum. J. Agric. Food Chem. 2016, 64, 2709-2718.

 

- Jeon, H.Y.; Kim, N.R.; Lee, H.W.; Choi, H.J.; Choung, W.J.; Koo, Y.S.; Ko, D.S.; Shim, J.H. Characterization of a novel maltose-forming alpha-amylase from Lactobacillus plantarum subsp. plantarum ST-III. J. Agric. Food Chem. 2016, 64, 2307-2314.

 

- Koo, Y.S.; Lee, H.W.; Jeon, H.Y.; Choi, H.J.; Choung, W.J.; Shim, J.H. Development and characterization of cyclodextrin glucanotransferase as a maltoheptaose-producing enzyme using site-directed mutagenesis. Protein Eng. Des. Sel. 2015, 28, 531-537.

 

박소현
  • 분야

    보건영양학 (지역사회영양, 영양역학, 영양정책)

  • 성명

    국문 박소현

  • 직위

    조교수

  • 연구실

    생명과학관 8519호

  • 연락처

    033-248-2134

  • 이메일

학력

1998-2002 이화여자대학교 생활과학대학 식품영양학과 [학사]

2003-2005 Tufts University, School of Nutrition Science andPolicy(Food Policy and Applied Nutrition 전공) [석사]

2007-2012 Johns Hopkins University, School ofPublic Health, Department of Internatonal Health(Human Nutrition 전공) [박사] 

주요경력

2002-2003 ㈜매일유업, 홍보팀 사원

2005-2006 한양대학교 의과대학 예방의학교실 연구원

2006-2007 보건복지부 건강기능식품 연구위원 (식품의약품안전청 영양평가팀 근무)

2010-2012 International Food Policy Research Institute, Data Analyst

2012-2014 한양대학교 의과대학 예방의학교실, 건강과 사회 연구소, 박사후 연구원

2014-2016 한양대학교 의과대학 예방의학교실, 건강과 사회 연구소, 연구교수

2012-2015 이화여자대학교, 동덕여자대학교, 고려대학교, 한양대학교 강사 

연구 및 저서

■ 논문
- Park S, KimSA, Kim MK, Cho SH, Choi BY. Trend of the anthropometric indices amongadolescents in an urban and a rural area in Korea over the period of1996-2005.  Korean Journal of Epidemiology 2006; 28(2): 189-198
- Kwon KI, Park S, Lee JH, Kim JY, Yoo KS, Lee JS, Kim SY, Sung HI, Nam HS,Kim JW, Lee HY, Park HK, Kim MC. Prevalence of nutrition labeling and claims onprocessed, and packaged food. Korean JCommunity Nutrition 2007; 12(2) : 206-213
- Kim JY, Lee JH, Park S, Yoo KS, Kwon KI, Lee JS, Kim SY, Sung HI, Nam HS, Kim JW,Lee HY, Park HK, Kim MC. Trans Fat Analysis in Foods.  FoodScience and Industry 2007; 40(1) : 22-26
- Kim JW, Kwon KI, Yoo KS, Park S, Lim CJ, Choi DW. NationalStrategic Planning For Facilitating the Development of New Drugs in the KoreaFood and Drug Administration.  J of the Korean Oil Chemists’ Soc 2008;25(4): 539-555
- Park S, Choi BY, Wang Y, Colantuoni E,Gittelsohn J. School and neighborhood nutrition environment and their association withstudents' nutrition behaviors and weight status in Seoul, South Korea.Journal of Adolescent Health 2013;53(5): 655-662
- ChristiansenK, Qureshi F, Schaible A, Park S,Gittelsohn J. Environmental factors that impact the eating behaviors of low-incomeAfrican American adolescents in Baltimore City. Journalof Nutrition Education and Behavior 2013; 45(6): 652-660
- Park S,Kang JH, Lawrence R, Gittelsohn J. Environmental influences on youth eatinghabits: Insights from parents and teachers in South Korea. Ecology of Food and Nutrition 2014; 5(4):347-362
- Park S, Lee J, KwonKI, Kim J,Byun JE, Kang BW, Choi BY, Park H. Early Adulthood: An Overlooked Age Group inNational Sodium Reduction Initiatives in South Korea. Nutrition Research and Practice 2014;8(6): 719-723 
- Park S, Lee EY, Gittelsohn J, Nkala Denis, ChoiBY. Understanding school health environment through interviews with keystakeholders in Lao PDR, Mongolia, Nepal and Sri Lanka. Health Education and Research 2015; 30(2): 285-297
- Lee J, Park S. Consumer attitudes, barriers,and meal satisfaction associated with sodium-reduced meal intake at worksitecafeterias. Nutrition Research and Practice 2015; 9(6): 644-649
- Lee J, Park S. Management of sodium-reducedmeals at worksite cafeterias: Perceptions, practices, barriers, and needs amongfood service personnel. Osong Public Health Research Perspectives 2016;7(2):119-126
- Park S, Lee J.“When operating a cafeteria, sales come before nutrition” - Finding barriers and facilitators toserving reduced-sodium meals in worksite cafeterias. Public Health Nutrition Sep 2015. Epubahead of publication.
- Gittelsohn J, Park S. “Schooland Community-Based Interventions,” in Pediatric Obesity: Etiology,Pathogenesis and Treatment (Freemark M, editor); Humana Press: New York,pp. 315-336.

 

박경호
  • 분야

    의학영양학

  • 성명

    국문 박경호

  • 직위

    조교수

  • 연구실

    생명과학관 8515호

  • 연락처

    033-248-2131

  • 이메일

학력

2003: 경희대학교 학사

2005: 경희대학교 동서의학대학원 석사

2009: 경희대학교 동서의학대학원 박사

주요경력

2020 ~ 현재: 래스 주식회사(교원 창업) 대표이사

2017 ~ 현재: 미래융합스쿨 의약신소재전공 겸임조교수

2014 ~ 2017: 미국 UCSF 산하 NCIRE-VA Medical Center 피부과 조교수(연구)

2009 ~ 2014: 미국 UCSF 피부과 박사후연구원 & 선임연구원

연구 및 저서

연구 분야

- 스핑고지질 대사체 중심의 질환(피부 & 암) 기전 연구 및 치료제 개발

- 피부장벽기능의 이해: 영양학적 접근

- 물질 분석 및 분석법 개발

 

주요 논문

1. Shin KO et al., Activation of SIRT1 enhances epidermal permeability barrier formation through ceramide synthase 2- and 3-dependent mechanisms. J Invest Dermatol 40:1435-1438, 2020

2. Lee J et al., Cathelicidin-related antimicrobial peptide regulates CD73 expression in mouse Th17 Cells via p38. Cells 9:1561, 2020

3. Shin KO et al., Both sphingosine kinase 1 and 2 coordinately regulate cathelicidin antimicrobial peptide production during keratinocyte differentiation. J Invest Dermatol 139:492-494, 2019

4. Park K et al., ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. PNAS 113: E1334-42, 2016 (Note: This article was featured in Cell Chemical Biology 23(3): 313-314, 2016)

5. Park K et al., Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway. J Biol Chem 286: 34121-30, 2011


See more contributions to science: https://pubmed.ncbi.nlm.nih.gov/?term=kyungho+park&sort=date

기타

■ 수상

2014 미국피부과학회/일본피부과학회 Junior Faculty Award

2014 미국피부과학회 Research Fellow Award

2011 제6회 국제 세라마이드학회 Speaker Award

 

■ 홈페이지

www.phdlass.com

전수경
  • 분야

    영양생리학, 분자영양학 (대사성 질환, 생리활성물질)

  • 성명

    국문 전수경

  • 직위

    조교수

  • 연구실

    생명과학관 8513호

  • 연락처

    033-248-2138

  • 이메일

학력

- 2014-2018 University of Illinois at Urbana-Champaign, Division of Nutritional Sciences (Ph.D.)

- 2011-2013 서울대학교 식품영양학과 (석사)

- 2007-2011 서울대학교 식품영양학과 (학사)

주요경력

- 2021.09-현재 한림대학교 식품영양학과 조교수

- 2018.09-2021.07 University of Pennsylvania, Division of Gastroenterology, Postdoctoral researcher

- 2021.03-2021.06 수원대학교 객원교수

연구 및 저서

- S Jeon et al. Spatiotemporal biodistribution of 13C-labeled natural and synthetic α-tocopherol in mice following a single oral dose. Nutrition Research 2021; 93: 79-86.

- DG Buyco et al. Experimental models of metabolic and alcoholic fatty liver disease. World Journal of Gastroenterology 2021; 27(1): 1-18.

- MJ Kuchan et al. Infant rhesus macaque brain α-tocopherol stereoisomer profile is differentially impacted by the source of α-tocopherol in infant formula. Journal of Nutrition 2020; 150(9): 2305-2313.

- J Correnti et al. Liver-specific ceramide reduction alleviates steatosis and insulin resistance in alcohol-fed mice. Journal of Lipid Research 2020; 61(7): 983-994.

- S Jeon et al. Alcohol effects on hepatic lipid metabolism (*). Journal of Lipid Research 2020; 61(4): 470-479. (*Selected in a special virtual issue from ASBMB)

- S Jeon et al. 13C-lutein is differentially distributed in tissues of an adult rhesus macaque following a single oral administration: a pilot study. Nutrition Research, 2019; 61: 102-108.

- S Jeon et al. Relationships of carotenoid-related gene expression and serum cholesterol and lipoprotein levels to retina and brain lutein deposition in infant rhesus macaques following 6 months of breastfeeding or formula feeding. Archives of Biochemistry and Biophysics 2018; 654: 97-104.

- S Jeon et al. Lutein is differentially deposited across brain regions following formula or breast feeding of infant rhesus macaques (*). Journal of Nutrition 2018; 148(1): 31-39. (*Selected as a featured article)

 

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